The existence of this polymorphism in CYP2D6 leads to non-performing enzyme variant and will be related to decreased therapeutic reaction when handled with codeine.

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^ S4 provided that in drug combos; see #Authorized status. ^ Class C1 just for reduced doses; see exemptions on Portaria SVS/MS 344/ninety eight. ^ Pharmacy drugs if ordered in a reduced dose from the accredited pharmacy or in minimal dose drug blend; see #Authorized standing.

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In 2019 Ireland was claimed to get to the verge of a codeine dependancy epidemic, As outlined by a paper while in the Irish Clinical Journal.

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